However, duration of disease and HbA1c did not differ significantly between the single and multiple autoantibody detection groups. Our pooled analysis found that autoantibody expression in children with T1DM was associated with age at diagnosis. Results: Seven papers on 1266 T1DM patients and 982 controls relevant to our study were included in the analysis. Purpose: To perform a meta-analysis concerning the association between autoantibodies and the risk of T1DM Methods: Published papers from PubMed, Embase, Cochrane, and Google Scholar were collected and analyzed using a fixed or random-effect model. However, a quantitative overview of all associated autoantibodies and their effectiveness in diagnosing T1DM is still lacking. The role of this variant as a susceptibility gene in T1DM development should be further confirmed by carrying out studies with a larger sample size.īackground: The association between autoantibodies and the risk of type 1 diabetes mellitus (T1DM) is well known. The autoantigenic variants of SLC30A8 of rs13266634 were not found statistically significant with T1DM. However, HbA1C and Fasting Blood Sugar (FBS) were found statistically significant (p=0.001, p=0.000) in T1DM patients compared to controls. Similarly other genotypes were also not found statistically significant. The CC genotype of rs13266634 was not found significantly associated with T1DM (p=0.08) but the OR was 2.7 CI=0.86 -9.00. The most frequently observed genotype was CC among cases as well as controls. The RFLP of PCR product was done using a restriction enzyme, Alu I for genotyping. Blood was drawn, DNA was extracted and amplified through PCR. Cases included 25 diagnosed patients of T1DM meeting American Diabetes Association (ADA) new criteria and controls were their first-degree relatives. A total of 50 subjects were enrolled (25 cases and 25 controls) in the study. This case-control study was carried out at Ziauddin Medical University (ZMU) jointly with Baqai Institute of Diabetology and Endocrinology (Baqai Medical University) from June to October 2019. Therefore, we aimed to determine the most frequent autoantigen SLC30A8 genotype and its association with T1DM in the Pakistani population. However, there is a controversy in the association of the SLC30A8 gene in the pathogenesis of T1DM and a dearth of data in our part of the world. The polymorphism in the SLC30A8 gene can identify the people at risk of T1DM. Therefore, there is a need for a molecular variant that can help in early diagnosis in these patients. Type 1 Diabetes Mellitus (T1DM), is a genetic disease, the prevalence of which is increasing due to delays in the diagnosis because of the absence of standard antibodies.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |